File Name: natural light and better healing after chemotherapy .zip
- Physical Activity and the Cancer Patient
- A Diet Plan for Before and After Colon Cancer Treatment
- What to include in a chemo-recovery kit
- Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects
Physical Activity and the Cancer Patient
Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively reduces the quality of life in cancer patients. Natural products including crude extracts, bioactive components-enriched fractions and pure compounds prepared from herbs as well as herbal formulas have been proved to prevent and treat cancer.
Of significant interest, some natural products can reduce chemotherapy and radiotherapy-induced oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity. This review focuses in detail on the effectiveness of these natural products, and describes the possible mechanisms of the actions in reducing chemotherapy and radiotherapy-induced side effects. Recent advances in the efficacy of natural dietary supplements to counteract these side effects are highlighted.
In addition, we draw particular attention to gut microbiotan in the context of prebiotic potential of natural products for the protection against cancer therapy-induced toxicities. We conclude that some natural products are potential therapeutic perspective for the prevention and treatment of chemotherapy and radiotherapy-induced side effects.
Further studies are required to validate the efficacy of natural products in cancer patients, and elucidate potential underlying mechanisms. Cancer is one of the most common causes of death worldwide Mcguire, Chemotherapy and radiotherapy are the most effective and extensive approaches for cancer management. However, chemotherapy, and radiotherapy-induced adverse effects including oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity, hinder the clinical uses.
Subsequently, these harmful effects often reduce the quality of life in cancer patients, and may lead to therapy discontinuation Shapiro, ; Turcotte et al. Therefore, it is important to develop effective management strategies against chemotherapy and radiotherapy-induced side effects. Natural products including crude extracts, bioactive components-enriched fractions, and pure compounds derived from herbs as well as herbal formulas have been proved to prevent and treat cancers Sanders et al.
Clinical trials and preclinical studies show that some natural products can reduce chemotherapy and radiotherapy-induced oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity.
Natural dietary supplements containing some ingredients such as Ginseng extract, Grape seed extract, and curcumin promote the recovery from severe illness, and relieve chemotherapy and radiotherapy-induced side effects. Gut microbiota plays the role in the modulation of drug action Curro, , possibly could evaluate the risk of severe gastrointestinal toxicity.
Herb medicine has potential to improve digestive health Peterson et al. The aim of this review is to summarize the recent evidence in detail for the effectiveness of natural products, and describe the possible mechanisms of the actions in reducing chemotherapy and radiotherapy-induced side effects. This review also draws particular attention to recent advances in the efficacy of natural dietary supplements, and the modulation of natural products on gut microbiotan for the protection against cancer therapy-induced toxicity.
Oral mucositis is a common complication in patients undergoing chemotherapy and radiotherapy, which is initiated partly by oxidative stress and inflammation. Plant-derived and other natural medicines with anti-inflammation are recently demonstrated to manage chemotherapy-induced oral mucositis Panahi et al. Plantago major is a most abundant herbaceous perennial plant that has been traditionally used for hundreds of years, and is effective as a wound healer with anti-ulcerative, anti-inflammatory, anti-bacterial, anti-viral, and anti-oxidant activities Adom et al.
A feasibility randomized triple-blind phase III clinical trial shows that P. Severe stomatitis may interrupt or discontinue cancer therapeutics, and increase the risk of local and systemic infection.
Japanese traditional medicine Kampo Hangeshashinto TJ effectively relieves chemotherapy-induced oral mucositis in gastric cancer and colorectal cancer patients by anti-oxidation and anti-inflammation Matsumoto et al. Chamomile Matricaria recutita is a medicinal plant widely used in traditional medicine for its anti-oxidant, anti-microbial, and anti-inflammatory actions Gomes et al. Aznol mouthwash combined with chamomile extract and Hangeshashinto, alleviates stomatitis in a small cohort of lung cancer patients treated with afatinib Kato et al.
Aloe vera , an herbal medicine in tropical area, has been used to treat skin disorders with anti-bacterial and wound-healing effects. Its mouthwash significantly reduces the intensity of chemotherapy-induced stomatitis and pain in clients with lymphoma and leukemia, and possibly improves the nutritional status of cancer patients Mansouri et al.
Natural nutritional products are also investigated to reduce chemotherapy and radiotherapy-induced oral mucositis. Turmeric the rhizome of Curcuma longa is a traditional spice and herb with many health benefits.
Turmeric and its active ingredient curcumin have anti-oxidant and anti-inflammatory properties. Curcumin mouthwash is observed to be better than chlorhexidine mouthwash in terms of rapid wound healing in adult patients with chemotherapy and radiotherapy-induced oral mucositis Patil et al.
The rhizome of Zingiber officinale ginger is also used as traditional medicine with health benefits to treat muscular aches and pains worldwide. Tocotrienols are natural compounds existed in vegetable oil, which are a promising analogs of vitamin E for cancer therapeutics by sensitizing cancer cells to chemotherapeutic agents Sailo et al. Quercetin, a natural flavonoid enriched in common vegetables and herbs, has anti-oxidative and anti-inflammatory effects.
Administered mg quercetin capsules twice daily for 4 weeks, can reduce the incidence of oral mucositis in patients who undergo high dose chemotherapy for blood malignancy Kooshyar et al. Honey produced by bees from flower nectar, is a folk medicine since ancient times in many countries. A meta-analysis indicates that honey can effectively reduce the incidence of chemotherapy and radiotherapy-induced oral mucositis Xu et al. Further clinical evidence demonstrates its effectiveness as a preventative and therapeutic measure for chemotherapy-associated oral mucositis in pediatric oncology patients Friend et al.
There is potential interaction between oral microenvironment and mucositis development. Honey treatment produces the significant reduction of oral mucositis associated Candida and aerobic pathogenic bacterial infection, and increases body weight, delays the onset of oral mucositis, and decreases the severity of pain Al Jaouni et al. In Turkey, black mulberry molasses is a foodstuff widely used as traditional intervention for the treatment of mucositis.
Recently, black mulberry molasses usage is demonstrated to be an effective intervention in the prevention of radiation-induced oral mucositis in head and neck cancer patients Demir Dogan et al.
Propolis is a natural product collected by honeybee worker, and contains flavonoids with anti-ulcer, anti-bacterial, anti-fungal, healing and anti-inflammatory effects Dodwad and Kukreja, Its water extract mouthwash efficiently prevents and heals chemotherapy or radiotherapy-induced oral mucositis in patients with head and neck cancers, or leukemia Javadzadeh Bolouri et al. However, early report of a double blind randomized placebo controlled trial shows that propolis cannot be recommended for severe oral mucositis in chemotherapy-treated pediatric patients Tomazevic and Jazbec, The most common gastrointestinal toxicities induced by chemotherapy and radiotherapy include nausea, vomiting and diarrhea.
In , Chen et al. Bacopa monnieri is used in several traditional systems of medicines for the management of epilepsy, depression, and neuropathic pain. Its bacoside-rich n-butanol fraction antagonizes cisplatin-induced retching and vomiting response Ullah et al.
Red Ginseng, a product with a steaming and drying process of the fresh ginseng, contains the majority of ginsenosides. Recently, a randomized double blind placebo-controlled trial demonstrates that Red Ginseng decreases symptom of nausea, vomiting, dyspnea and fatigue, and its efficacy and safety can improve life quality in patients receiving six cycles of adjuvant taxane- and platinum-based chemotherapy after cytoreductive surgery Kim H.
A phase II randomized double-blind placebo-controlled study shows that safe and well-tolerated 6-gingerol improves the overall complete response rate in nausea and vomiting, appetite as well as quality of life in cancer patients with surgical resection of primary tumor and moderately to highly emetogenic adjuvant chemotherapy Konmun et al. Rhus coriaria , a flowering shrub, possesses anticancer effect against human colorectal cancer cells and triple-negative breast cancer cells El Hasasna et al.
Its resin extract also attenuates angiogenesis and is used in treatment and management of cancer in Kenya Ochwang'i et al. Bunium persicum is a perennial plant in Iran.
A randomized, double blind, crossover clinical trial shows that Persumac, a combination of R. Huang-Qin decoction is first described in Chinese canonical medicine about years ago for the treatment of different gastrointestinal symptoms, including nausea, vomiting and diarrhea. This decoction attenuates irinotecan-induced gastrointestinal toxicity and diarrhea in rats possibly via regulating glycine, serine and threonine pathway as well as bile acid metabolism homeostasis.
Scutelleria baicalensis may play a crucial role in the therapeutic effect of this decoction on irinotecan-induced diarrhea Cui et al. Of note, nutrient absorption and digestion of gastrointestinal tract may be compromised during chemotherapy and radiotherapy-induced damage to non-cancerous gastrointestinal mucosa. In , Mahendran et al. Other animal experiments confirm the efficacy of herbal medicines on intestinal mucositis. Wei-Chang-An pill, a traditional Chinese pharmaceutical preparation, possesses anti-inflammatory advantage and gastrointestinal regulation in digestive diseases.
This pill promotes the recovery of intestinal function in 5-fluorouracil-induced intestinal mucositis in mice via relieving severe diarrhea and inhibiting gastric emptying and gastrointestinal transit in intestinal homeostasis Chen Y. Bu-Zhong-Yi-Qi decoction, a Chinese traditional herbal medicine, is widely used in Asia as an alternative treatment to reduce side effects of chemotherapy. This decoction protects against 5-fluorouracil-induced intestinal mucositis in mice Gou et al.
Saireito TJ is often used to treat inflammatory diseases such rheumatoid arthritis, systemic lupus erythematodes, and nephrotic syndrome. TJ can reduce 5-fluorouracil-induced intestinal mucositis in mice by inhibiting cytokine-mediated apoptosis in intestinal crypt cells Kato et al. The root of Rehmannia glutinosa is one of the commonly used Chinese herbal medicines.
Its steamed products alleviate methotrexate-induced rat gut mucositis by inhibiting oxidative stress and inflammation Shi et al. Licorice G. Rutin with free radical scavenging and anti-inflammatory actions also significantly protects against methotrexate-induced intestinal lesion damage in rats Gautam et al. Nigella sativa seed is a traditional herbal medicine throughout the world. Its oil is beneficial in a wide range of gastrointestinal disorders, and significantly attenuates cisplatin-induced alteration of brush border membrane enzymes, carbohydrate metabolism and antioxidant system in the intestine of rats Shahid et al.
Thymoquinone, a major principle active ingredient derived from this seed oil, improves gastrointestinal function as well as the redox and metabolic status of intestinal mucosal tissue in rat model of cisplatin-induced intestinal injury Shahid et al.
Radiotherapy-induced esophagitis and enteropathy are the major issues for long-term cancer survivors Kim J. Chinese herbal medicine Zhu-Ye-Shi-Gao granule can treat recurrent oral ulcer and chronic pharyngitis. A randomized controlled trial shows that this granule decreases the incidence and grade of acute radiation-induced esophagitis, demonstrating its efficacy and safety in patients with lung, esophagus or mediastinal cancer Wang L.
Oroxylin is a natural flavonoid isolated from S. Grape seed extracts and its proanthocyanidins are commonly utilized as dietary supplements for anti-oxidant property in cancer patients Bagchi et al.
A systematic review of preclinical studies shows that grape seed extracts may alleviate chemotherapy and radiotherapy-induced toxicity Olaku et al. Grape seed proanthocyanidins have radioprotective action Katiyar et al.
Green tea contains a high content of catechins. Compared with placebo group, its tablet shows less frequency and severity of radiotherapy-induced diarrhea but not vomiting in patients with abdomen and pelvic malignancy after receiving radiotherapy Emami et al. Therefore, an extract mixture of green tea and grape seed is considered to be a good radioprotector and immune modulator, indicating its possible use as an adjuvant during radiotherapy El-Desouky et al. Silymarin, a complex of flavonolignans extracted from milk thistle Silybum marianum , has been used for centuries as the treatment of different diseases with anti-oxidant and anti-inflammatory activities.
Its major constituent silibinin is reported to radiosensitize prostate cancer by inhibiting DNA repair signaling Nambiar et al. Nephelium lappaceum is an importantly commercial crop with nutrients and bioactive constituents.
Clerodendrum infortunatum rich in flavonoids and saponins is used in Ayurvedic and Siddha traditional medicine. The gut microbiota is a vast community of synergistic bacterial species providing health benefits to the host Westfall et al.
Gastrointestinal tract forms the targets of chemotherapy and radiotherapy-induced toxicity, causing imbalance in the gut microbiota dysbiosis Serban, ; Wardill and Tissing, ; Bruneau et al. Fucoidans, a group of certain fucose-containing sulfated polysaccharides, are naturally occurring components of certain edible seaweeds and echinoderms in Japan and Korea.
Fucoidan intervention can relieve cyclophosphamide-induced intestinal mucosal injury by decreasing inflammation and increasing tight junction protein expression in mice. Low molecular weight of fucoidan 50 kDa remarkably increases the abundance of short chain fatty acids SCFAs producer Coprococcus, Rikenella , and Butyricicoccus species within the intestinal mucosa compared with the cyclophosphamide group, possibly as an effective supplement to protect against intestinal mucosal barrier damage during chemotherapy via gut microbiota Shi et al.
A Diet Plan for Before and After Colon Cancer Treatment
Your colon is a key player in your digestive system, which processes and delivers nutrients throughout your body to keep you strong and healthy. As such, eating well and maintaining a nutritious diet is one of the best ways you can prepare for and recover from colon cancer treatments. Here are some key tips for building a diet plan that will help you keep your colon in the best shape possible before and after treatment. For this reason, your diet plan should include foods that fulfill these needs. Additionally, cancer treatments like chemotherapy can be extremely difficult on your body, as they sometimes destroy healthy tissue as well as cancerous. To rebuild strength, experts say there are some key areas to pay attention to.
In many cases, chemotherapy can help shrink tumors or stop them from growing. But certain types of chemotherapy medications can also weaken your immune system. That can leave you vulnerable to infections. Ask your doctor if you should take any protective drugs to help boost your immune system or prevent infection. CSF treatments can be administered as an injection or a skin patch. The treatments help promote the growth of blood cells and reduce your risk of infection.
What to include in a chemo-recovery kit
Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively reduces the quality of life in cancer patients. Natural products including crude extracts, bioactive components-enriched fractions and pure compounds prepared from herbs as well as herbal formulas have been proved to prevent and treat cancer. Of significant interest, some natural products can reduce chemotherapy and radiotherapy-induced oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity.
In the past, people being treated for a chronic illness an illness a person may live with for a long time, like cancer or diabetes were often told by their doctor to rest and reduce their physical activity. This is good advice if movement causes pain, rapid heart rate, or shortness of breath. But newer research has shown that exercise is not only safe and possible during cancer treatment, but it can improve how well you function physically and your quality of life. Too much rest can lead to loss of body function, muscle weakness, and reduced range of motion. So today, many cancer care teams are urging their patients to be as physically active as possible during cancer treatment.
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Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects
For more info, and if you live in NJ: Read more. This information explains what to expect after you finish your chemotherapy treatment for breast cancer. Most people are relieved when they finish chemotherapy, but some people may feel worried. They could answer your questions and support you at each visit. Your doctor and nurses will continue to care for you now and in the future.
Chemotherapy often abbreviated to chemo and sometimes CTX or CTx is a type of cancer treatment that uses one or more anti-cancer drugs chemotherapeutic agents as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent which almost always involves combinations of drugs , or it may aim to prolong life or to reduce symptoms palliative chemotherapy. Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer , which is called medical oncology. The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis cell division or induce DNA damage , which is why inhibition of DNA repair can augment chemotherapy. The development of therapies with specific molecular or genetic targets, which inhibit growth-promoting signals from classic endocrine hormones primarily estrogens for breast cancer and androgens for prostate cancer are now called hormonal therapies. By contrast, other inhibitions of growth-signals like those associated with receptor tyrosine kinases are referred to as targeted therapy. Importantly, the use of drugs whether chemotherapy, hormonal therapy or targeted therapy constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body.
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Keywords: natural products, cancer, chemotherapy, radiotherapy, side effects promote the recovery from severe illness, and relieve chemotherapy and Herb medicine has potential to improve digestive health (Peterson et al., ). These studies may help to shed light upon the preventive process of.
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